Description

SS-31 Peptide — 10 mg (RUO)

SS-31, also known as elamipretide (MTP-131), is a synthetic mitochondria-targeting tetrapeptide. It belongs to the Szeto-Schiller (SS) class of aromatic-cationic peptides and has been studied in laboratory and preclinical models involving mitochondrial function, cardiolipin interaction, oxidative stress, cellular energy production, and tissue-protective mechanisms.

Supplied as a 10 mg lyophilized research peptide for controlled laboratory investigations.

For laboratory research use only. Not for human or animal consumption.

OVERVIEW

SS-31 is a cell-permeable tetrapeptide characterized by an alternating aromatic-cationic amino acid structure. It is notable in research for its selective association with the inner mitochondrial membrane, where studies have examined its binding to cardiolipin, a phospholipid central to mitochondrial membrane architecture and electron transport.

Laboratory research has investigated SS-31 in relation to mitochondrial bioenergetics, including electron transport chain efficiency, ATP production, reactive oxygen species (ROS) generation, and mitochondrial membrane stability.

Preclinical studies have also explored SS-31 in cellular and animal models involving ischemia-reperfusion injury, oxidative stress, mitochondrial dysfunction, and age-related cellular decline. These findings remain investigational and do not establish SS-31 as an approved treatment or therapeutic product.

PRODUCT SPECIFICATIONS

(Verify all values against the applicable batch Certificate of Analysis when available.)

Compound: SS-31 / Elamipretide (MTP-131)
Sequence: D-Arg-Dmt-Lys-Phe-NH₂ (Dmt = 2,6-dimethyltyrosine)
Quantity: 10 mg
Form: Lyophilized powder
Molecular Formula: C₃₂H₄₉N₉O₅ (confirm against batch CoA)
Molecular Weight: 639.79 g/mol (free base; confirm against batch CoA)
CAS: 736992-21-5 (elamipretide free base; salt forms differ — confirm against batch CoA)
Storage: 2–8°C recommended; protect from light and moisture
Purity: Refer to the current batch Certificate of Analysis

Specifications should be verified against the applicable batch CoA. Modified or salt forms (such as the acetate) may have different molecular weights, formulas, and CAS numbers.

RESEARCH APPLICATIONS

• Mitochondrial function research
• Cardiolipin interaction studies
• Oxidative stress and ROS investigations
• Electron transport chain research
• ATP / cellular energy production models
• Ischemia-reperfusion injury models
• Mitochondrial membrane stability studies
• Cellular aging and senescence research
• Skeletal and cardiac muscle cell models
• Mitochondrial biogenesis investigations

RESEARCH BACKGROUND

SS-31 is a member of the Szeto-Schiller family of aromatic-cationic peptides developed to concentrate selectively within mitochondria. Unlike many peptides that act at cell-surface receptors, SS-31 has been studied for its association with the inner mitochondrial membrane and its interaction with cardiolipin.

In laboratory studies, SS-31 has been investigated for its effects on mitochondrial bioenergetics in cellular and tissue models. Research has reported interactions involving cardiolipin binding, stabilization of the electron transport chain, reduction of reactive oxygen species, and preservation of mitochondrial membrane potential.

Additional preclinical research has explored SS-31 in animal models of ischemia-reperfusion injury, heart and skeletal muscle dysfunction, kidney injury, and age-associated mitochondrial decline, as well as in delivery systems designed to target mitochondrial compartments. These studies are useful for understanding mitochondrial energetics, oxidative-stress signaling, and cellular-protection mechanisms.

Results from cell and animal models should not be interpreted as evidence of safety, efficacy, dosage, or approved therapeutic use in humans.

RESEARCH USE ONLY

This product is intended strictly for qualified laboratory research.

Not for human consumption. Not for veterinary use. Not for injection. Not for therapeutic or diagnostic applications. Not intended to diagnose, treat, cure, or prevent any disease or medical condition.

Use is limited to qualified professionals conducting controlled laboratory investigations in accordance with applicable institutional, regulatory, and safety requirements.

Certificate of Analysis available for applicable product batches.